Comparison of the antineuraminidase antibody response to vaccination with intact virus and subunit preparations obtained by different techniques of the influenza virus strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H3N2)
Identifieur interne : 002822 ( Main/Exploration ); précédent : 002821; suivant : 002823Comparison of the antineuraminidase antibody response to vaccination with intact virus and subunit preparations obtained by different techniques of the influenza virus strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H3N2)
Auteurs : J. Drescher [Allemagne] ; U. Desselberger [Allemagne]Source :
- Comparative Immunology, Microbiology and Infectious Diseases [ 0147-9571 ] ; 1980.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- classification : Influenza A virus.
- immunology : Influenza A virus, Influenza Vaccines, Neuraminidase.
- Teeft :
- Animals, Antibody mixtures, Antibody response, Antibody titers, Antigenic, Antigenic determinants, Antigenic relationship, Antigenic variation, Antigens, Viral, Antineuraminidase antibodies, Avec, Bromelain, Composantes virales, Different subunit preparations, Drescher, Enzyme inhibition test, Epitopes, Hemagglutinating subunits, Influenza, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza neuraminidases, Influenza virus, Influenza virus strains, Intact virus, Neuraminidase, Neuraminidases, Photometric, Photometric hemagglutination inhibition test, Photometric method, Recombinant, Representative examples, Sediment fractions, Serum dilution yieldingbinding, Subunit, Subunit preparations, Testing sera, Vaccination, Vaccination avec, Virus entier.
Abstract
Abstract: Chickens were vaccinated comparatively with intact influenza virus of the strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H3N2) and with viral subunits and the antineuraminidase (AN) antibody response was examined.Subunit preparations were obtained by treatment of virus with either, bromelain, Sarkosyl and Nonidet.The AN antibody response was recorded by means of a photometric method capable of analyzing mixtures of AN antibodies oriented to antigenically different N2 neuraminidases [1].It was found that vaccination with some of the subunit preparations yielded AN antibody response oriented to heterologous neuraminidase, while vaccination with the corresponding intact viruses gave AN antibody response oriented to homologous neuraminidase, only. The same conclusion was reached when testing sera by means of the enzyme inhibition test as recommended by the WHO.These results were interpreted to suggest that the neuraminidases of the strains tested are antigenically inhomogeneous and that disruption of virus can result in the release of antigenic components which are not directly discernible in intact virus.
Résumé: Des poules ont été vaccinées avec du virus grippal entier et avec des composantes virales et les réponses en anticorps anti N.A. ont été déterminées. Les composantes virales ont été préparées par traitement de virus avec éther, bromelain, Sarkosyl et Nonidet.Les réponses en anticorps anti N.A. ont été déterminées avec une méthode photométrique capable d'analyser des mélanges d'anticorps dirigés contre des neuraminidases N2 différentes [1].L'examen sérologique montra que la vaccination avec quelques-unes des préparations des composantes virales donnait des anticorps orientés contre des neuraminidases hétérologues.Aprés la vaccination avec le virus entier, on a observé des anticorps orientés exclusivement contre la neuraminidase homologue. On a confirmé cette conclusion par la détermination des anticorps avec la méthode de l'inhibition de la neuraminidase proposée par l'O.M.S.Les résultats sont interprétés de telle façon que les souches examinées étaient inhomogènes au point de vue antigénique et que la rupture du virus peut démasquer des antigènes qui ne sont pas discernables dans le virus entier.
Url:
DOI: 10.1016/0147-9571(80)90060-0
Affiliations:
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xml:lang="fr"><term>Animaux</term><term>Antigènes viraux</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccination</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Chickens were vaccinated comparatively with intact influenza virus of the strains A/Sing/1/57 (H2N2), A/Hong Kong/1/68 (H3N2) and A/Port Chalmers/1/73 (H3N2) and with viral subunits and the antineuraminidase (AN) antibody response was examined.Subunit preparations were obtained by treatment of virus with either, bromelain, Sarkosyl and Nonidet.The AN antibody response was recorded by means of a photometric method capable of analyzing mixtures of AN antibodies oriented to antigenically different N2 neuraminidases [1].It was found that vaccination with some of the subunit preparations yielded AN antibody response oriented to heterologous neuraminidase, while vaccination with the corresponding intact viruses gave AN antibody response oriented to homologous neuraminidase, only. The same conclusion was reached when testing sera by means of the enzyme inhibition test as recommended by the WHO.These results were interpreted to suggest that the neuraminidases of the strains tested are antigenically inhomogeneous and that disruption of virus can result in the release of antigenic components which are not directly discernible in intact virus.</div><div type="abstract" xml:lang="fr">Résumé: Des poules ont été vaccinées avec du virus grippal entier et avec des composantes virales et les réponses en anticorps anti N.A. ont été déterminées. Les composantes virales ont été préparées par traitement de virus avec éther, bromelain, Sarkosyl et Nonidet.Les réponses en anticorps anti N.A. ont été déterminées avec une méthode photométrique capable d'analyser des mélanges d'anticorps dirigés contre des neuraminidases N2 différentes [1].L'examen sérologique montra que la vaccination avec quelques-unes des préparations des composantes virales donnait des anticorps orientés contre des neuraminidases hétérologues.Aprés la vaccination avec le virus entier, on a observé des anticorps orientés exclusivement contre la neuraminidase homologue. On a confirmé cette conclusion par la détermination des anticorps avec la méthode de l'inhibition de la neuraminidase proposée par l'O.M.S.Les résultats sont interprétés de telle façon que les souches examinées étaient inhomogènes au point de vue antigénique et que la rupture du virus peut démasquer des antigènes qui ne sont pas discernables dans le virus entier.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Drescher, J" sort="Drescher, J" uniqKey="Drescher J" first="J" last="Drescher">J. Drescher</name></noRegion><name sortKey="Desselberger, U" sort="Desselberger, U" uniqKey="Desselberger U" first="U" last="Desselberger">U. Desselberger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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